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Chronic Fatigue Syndrome (CFS) is classified as fatigue lasting more than 6 months, which is accompanied by other symptoms. These include muscle and joint pain, sore throat, post exercise fatigue lasting longer than 24 hours, and cognitive difficulties. It is generally not relieved by rest, and has substantial effects on the person’s activity levels.

Diagnosis can sometimes be difficult due to the varying symptom criteria (Fukuda, ICC, or CCC), and because there is no objective blood or bio-marker available. Often people are labelled with chronic fatigue after no other cause can be found, or else no diagnosis is given due to doctors not believing that it exists. This is frustrating for individuals who are suffering.

 

Possible Causes of Chronic Fatigue

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MitochondriaChronic Fatigue Mitochindria

The mitochondria are ancient bacteria that are responsible for creating energy in the form of ATP. These mitochondria are very unique. They have 2 membranes made from phospholipids, and contain an electron transport chain on the inner membrane. This is an important chain that contains 5 channels that pass electrons from one to the other, with the end goal being the creation of ATP.

Mitochondria need many nutrients to function. For example, Carnitine and Vitamin B2 are needed to move nutrients through the membranes.   They also need Vitamin B3, CoQ10, oxygen, Alpha-lipoic acid, Ribose, metabolites created in the citric acid cycle, and other nutrients. The Organic Acid Test includes many of these nutrients, which provides a good insight into energy production and causes for chronic fatigue.

There are other options for increasing mitochondrial function in the body. Using a rebounder for 10mins per day, specific breathing exercises, and even putting your feet in the ocean can help improve the transport of electrons.

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Oxidative stress and Inflammation

Oxidative stress is defined as an “imbalance between the production of free radicals (oxidizing molecules) and the ability to reduce them with antioxidants”. This oxidative stress will damage various parts of our biology, but in the case of chronic fatigue patients, it will damage their mitochondria. This causes a poor ability to make energy.

High oxidative stress will deplete antioxidants further, which makes people more susceptible to other issues that relate to their immune system, food and chemical sensitivities, mood issues, digestive concerns, and can greatly affect pain sensitivity.

Increasing antioxidant capabilities provide a good foundation to build from. There are specific nutrients that can be utilised according to the person’s case to help with this.

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Methylation and GeneticsGenetics Chronic Fatigue

Methylation is needed to make various compounds, one being the body’s master antioxidant “Glutathione”. Glutathione regulates the immune system, detoxes harmful toxins and heavy metals, and also helps to reduce free radicals within the mitochondria. It does this in collaboration with the SOD (superoxide dismutase) enzyme. There are many other genes that code for important enzymes needed to create glutathione, as well as increasing serotonin, lowering inflammation, and optimizing energy production.

Glutathione is also needed for the proper functioning of Vitamin B12, which is hugely involved in energy production, making red blood cells for oxygen delivery, and reducing oxidative stress in itself.

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Digestion

The gut is the foundation of our health. The bacteria that reside there exist in a delicate balance, which when out of balance, can cause noticeable symptoms. These may be gastrointestinal bloating, irregular bowel movements, pain and nausea, but it can also cause severe fatigue.

Parasitic infections such as Blastocystis, Dientamoeba, or Giardia are associated with chronic fatigue.   An overgrowth of beneficial bacteria such as Entereococcus, Streptococcus, and other lactic acid producing bacteria are also likely candidates, and of course, so is Candida Albicans and SIBO (Small Intestinal Bacterial Overgrowth).

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Hypoxia

Hypoxia occurs when the body receives poor delivery of oxygen to the cells.   Following exercise, those with CFS have a significantly lower oxygen delivery to their muscles, which results in pain and a longer time period to recover. It may also be the causse for impaired concentration, memory loss, inability to focus vision, and poor motor coordination.

CFS patients are often shallow chest breathers. This reduces oxygen delivery to the blood due to insufficient oxygenation of the lower parts of the lungs.  (Shallow breathing also stimulates of the sympathetic nervous system). Other causes of poor oxygen delivery may include sleep apnoea, poor air quality in general, stress, or pulmonary conditions.

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SerotoninChronic Fatigue Symptoms

Evidence exists that suggests serotonin plays a role on the pathogenesis of CFS. Research shows that CFS sufferers have a lower amount of serotonin receptors in the brain.  This leads to depression, and fatigue of varying severity.

There is an association between serotonin protein polymorphisms (5-HTT/ SLC6A4), and the occurrence of low serotonin, depression and also chronic fatigue. This is often the link between chronic fatigue and fibromyalgia, because serotonin acts as a pain mediator. The more serotonin you have, the less pain you experience. For this reason, antidepressants are often the first treatment approach for Fibromyalgia sufferers, and often CFS as well.

There are dedicated nutrients that can be used to increase serotonin production naturally. Methylation and gut optimisation are also an important players in serotonin  production.

 

Treatment Options

Treatment is multilayered according to what is necessary for each person.   Organic Acid testing is a good strategy for gaining information on mitochondria.  It also includes gut markers, serotonin, antioxidant capabilities, and other specific nutrients. The “Up and At Em’” Chronic Fatigue program is designed around this test to gain extensive information from the outset.